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leprae. Anin silicostudy was conducted to comprehend the molecular interactions amongst DNA gyrase and WQ compounds. WQ-3334 and WQ-3810 had been shown to obtain larger inhibitory activity againstM. lepraeDNA gyrase than others. Also, Examination employing quinolone-resistantM. lepraeDNA gyrases showed that WQ-3334 had bigger inhibitory action than